LONDON — Syngenta has rejected a second takeover approach from Monsanto.

Syngenta of Switzerland received another letter from Monsanto on Saturday, June 6, essentially repeating its prior offer to acquire the company for about $45 billion. Syngenta rejected a takeover bid by Monsanto in May, in part citing potential regulatory concerns. The latest offer added a $2 billion breakup fee if the merger proved unpalatable to regulators, which Syngenta said was “wholly inadequate” and “paltry.”

In rejecting the prior offer, Syngenta said Monsanto’s bid undervalued Syngenta’s prospects and underestimated “the significant execution risks, including regulatory and public scrutiny at multiple levels in many countries.”

On Monday, Syngenta said that its board, in conjunction with its legal advisers, did not believe that the regulatory concerns would be resolved by “a pre-agreed and pre-announced package of horizontal divestitures, which is Monsanto’s proposed approach.”

Monsanto has said that it would sell Syngenta’s seed business and other overlapping businesses.

If the deal were announced and was not consummated, it could cause “significant harm and value destruction for Syngenta and its shareholders,” Syngenta said.

The deal would create an agricultural behemoth, combining Monsanto, the world leader in seeds and genetically engineered traits, such as herbicide resistance, with Syngenta, the largest producer of agricultural chemicals.

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